updated 08:10 pm EST, Mon January 20, 2014
Problem reproduced -- no Wacom supplied fix provides relief
Widespread reports are surfacing of some sort of incompatibility between Wacom's driver package, OS X 10.9 "Mavericks," and Adobe Creative Cloud products. Users are reporting serious lag between input and recognition, crashes from Creative Cloud, and extremely high CPU usage, often necessitating a reboot to regain system stability. As of yet, there is no official fix from Wacom, other than a reinstallation of the driver, which does not seem to fix the problem.
Wacom claims that "the latest tablet driver 6.3.7-3 (on the Wacom US download site) is compatible with Maverick without major issues. In case of problems, we recommend to uninstall and reinstall the driver. [Users] may, however, need to update [their] application software, if it runs slower on the new OS."
The Intuos line appears to be most affected by the problem, with users reporting that as soon as a render is started, the pointer lag becomes so severe that the tablet is useless. The lag does not affect USB mice, such as Apple mice or trackpads, from functioning properly. Besides a driver install, Wacom also recommends an install of the AutoCAD preview, which refreshes application caches, but users have reported limited success with this step.
MacNN was able to reproduce the problem. We started with no issues with the latest driver and an Intuos 5 on a variety of hardware including the new Mac Pro, a 2010 MacBook Pro, and a 2009 Mac Pro tower running OS X 10.8 "Mountain Lion." An upgrade to OS X 10.9 "Mavericks" instigated the problem on all of our testing hardware. None of Wacom's solutions provided us any relief from the issue. Following completion of the render, system performance and input returned to normal, until the next render.